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Synthesis of a biodegradable polymeric supramolecular assembly for drug delivery
Author(s) -
Ooya Tooru,
Mori Hideharu,
Terano Minoru,
Yui Nobuhiko
Publication year - 1995
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.1995.030160405
Subject(s) - ethylene glycol , supramolecular chemistry , drug delivery , covalent bond , biodegradable polymer , drug carrier , rotaxane , polymer , materials science , nanotechnology , combinatorial chemistry , chemistry , polymer chemistry , organic chemistry , molecule
A novel design of a biodegradable carrier for drug delivery was established by constructing a supramolecular assembly of drugs and polymer backbones without any covalent bonds. A biodegradable polyrotaxane was synthesized in which α‐cyclodextrins (α‐CDs) as drug carriers were threaded onto poly(ethylene glycol) chains which then were capped at each chain end by L ‐phenylalanine via peptide linkages. The release of α‐CDs was observed only when the terminal peptide linkages were degraded.