Synthesis of a biodegradable polymeric supramolecular assembly for drug delivery | Zendy

Ooya Tooru | Zendy; Mori Hideharu | Zendy; Terano Minoru | Zendy; Yui Nobuhiko | Zendy

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Synthesis of a biodegradable polymeric supramolecular assembly for drug delivery

Author(s) -

Ooya Tooru,

Mori Hideharu,

Terano Minoru,

Yui Nobuhiko

Publication year - 1995

Publication title -

macromolecular rapid communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.348

H-Index - 154

eISSN - 1521-3927

pISSN - 1022-1336

DOI - 10.1002/marc.1995.030160405

Subject(s) - ethylene glycol , supramolecular chemistry , drug delivery , covalent bond , biodegradable polymer , drug carrier , rotaxane , polymer , materials science , nanotechnology , combinatorial chemistry , chemistry , polymer chemistry , organic chemistry , molecule

A novel design of a biodegradable carrier for drug delivery was established by constructing a supramolecular assembly of drugs and polymer backbones without any covalent bonds. A biodegradable polyrotaxane was synthesized in which α‐cyclodextrins (α‐CDs) as drug carriers were threaded onto poly(ethylene glycol) chains which then were capped at each chain end by L ‐phenylalanine via peptide linkages. The release of α‐CDs was observed only when the terminal peptide linkages were degraded.

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