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Temperature‐induced phase transition behaviors of random vs. graft copolymers of N ‐isopropylacrylamide and acrylic acid
Author(s) -
Chen Guohua,
Hoffman Allan S.
Publication year - 1995
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.1995.030160304
Subject(s) - bioadhesive , poly(n isopropylacrylamide) , copolymer , acrylic acid , polymer chemistry , acrylic resin , lower critical solution temperature , phase transition , materials science , drug delivery , chemical engineering , chemistry , polymer , nanotechnology , composite material , thermodynamics , coating , physics , engineering
Graft copolymers of poly( N ‐isopropylacrylamide) (PNIPAAm) on a poly(acrylic acid) backbone retain the temperature‐induced phase transition behavior of PNIPAAm over a wide range of compositions even at pH 7,4 and should be useful for sustained‐release, bioadhesive drug delivery systems at physiologic conditions.