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An Easy‐to‐Fabricate Hydrogel Platform with Tunable Stiffness and Cell Anchorage: Validation of Its Feasibility in Modulating Sonic Hedgehog Signaling Pathway Physically
Author(s) -
Yu Tingting,
Hu Ke,
Xu Qiufan,
Xu Xueqin,
Du Chunyue,
Zhao Yinyi,
Yan Sen,
Wang Wei,
Tang Shijia,
Yue Shen,
Zhang Xiya,
Wang Danlei,
Zhang Feimin,
Cheng Steven Yan,
Gu Ning
Publication year - 2020
Publication title -
macromolecular materials and engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 96
eISSN - 1439-2054
pISSN - 1438-7492
DOI - 10.1002/mame.202070010
Subject(s) - sonic hedgehog , materials science , stiffness , hedgehog signaling pathway , biomedical engineering , signal (programming language) , adhesion , cell adhesion , nanotechnology , signal transduction , composite material , computer science , microbiology and biotechnology , biology , engineering , programming language
Back Cover : In article number 1900759, Feimin Zhang, Steven Yan Cheng, Ning Gu, and co‐workers develop an IPN hydrogel group with gradient stiffness and cell anchor points, and report that the matrix stiffness and adhesion property functions as key regulators to determine the final output of “Sonic Hedgehog” (Shh) signaling. These results indicate the feasibility of applying this hydrogel platform to low‐cost, high throughput screening of signal pathways which are responsive to the biophysical changes of microenvironments.