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Preparation and Characterization of PHBV/PEO/AZ‐Gelatin Electrospun Mats with Photochemical Surface Modification: The Role of AZ‐Gelatin
Author(s) -
Xu Yongjing,
Lu Hongwei,
Sun Chenkai,
Zou Liming,
Yin Hai,
Li Wengang
Publication year - 2020
Publication title -
macromolecular materials and engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 96
eISSN - 1439-2054
pISSN - 1438-7492
DOI - 10.1002/mame.202000344
Subject(s) - gelatin , materials science , electrospinning , surface modification , chemical engineering , adhesion , tissue engineering , porosity , fiber , polymer chemistry , composite material , polymer , chemistry , biomedical engineering , organic chemistry , medicine , engineering
As ideal tissue engineering scaffold, surface feature plays an important role in cell adhesion and proliferation. In order to improve cytocompatibility of poly(3‐hydroxybutyrate‐co‐hydroxyvalerate) (PHBV) and polyethylene oxide (PEO) synthetic materials, in this study, photochemical surface modification is applied in electrospinning field for the first time. Azidobenzoic acid‐modified gelatin (AZ‐gelatin) as bioactive protein is successfully fixed on PHBV/PEO electrospun mats by photochemical technique without any crosslinking agent. In vitro degradation and cell culture results show that PHBV/PEO/AZ‐gelatin electrospun mats have excellent cell adhesion and proliferation compared with PHBV and PHBV/PEO electrospun mats. But, by contrast with PHBV/PEO electrospun mats, the fiber diameter of PHBV/PEO/AZ‐gelatin mats increased, and the porosity and mechanical properties decrease. Nonetheless, PHBV/PEO/AZ‐gelatin‐0.01 mg mL −1 electrospun mats have shown better morphology (fiber diameter 600 nm, porosity 88%), mechanical properties (4.2 MPa), and water vapor transmission rate (2301 g m −2 day −1 ), which has great potential as artificial skin scaffold in tissue regeneration field.