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Knitted Silk Fibroin‐Reinforced Bead‐on‐String Electrospun Fibers for Sustained Drug Delivery Against Colon Cancer
Author(s) -
Ma Panpan,
Gou Shuangquan,
Wang Min,
Chen Jiucun,
Hu Wei,
Xiao Bo
Publication year - 2018
Publication title -
macromolecular materials and engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 96
eISSN - 1439-2054
pISSN - 1438-7492
DOI - 10.1002/mame.201700666
Subject(s) - fibroin , materials science , camptothecin , drug delivery , polygon mesh , nanofiber , electrospinning , nanotechnology , biomedical engineering , composite material , silk , chemistry , polymer , computer science , organic chemistry , computer graphics (images) , medicine
Bead‐on‐string electrospun fibers containing camptothecin (CPT) are fabricated on the surface of knitted silk fibroin (SF) meshes. Microscopic characterization reveals that the bead‐on‐string structure is prepared successfully and CPT is mainly located within the beaded structure. Interestingly, the CPT‐loaded beaded SF mesh (CPT‐SF mesh) has excellent mechanical properties. More importantly, it is able to perform a sustained CPT release without burst release. In vitro cytotoxicity tests further indicate that the CPT‐SF mesh shows much stronger anticolon cancer activity in comparison with SF meshes and beaded SF meshes. Hence, the CPT‐SF mesh has great potential as a promising local drug delivery system for colon cancer treatment.