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Mild and Effective Polymerization of Dopamine on Keratin Films for Innovative Photoactivable and Biocompatible Coated Materials
Author(s) -
Posati Tamara,
Ferroni Claudia,
Aluigi Annalisa,
Guerrini Andrea,
Rossi Francesca,
Tatini Francesca,
Ratto Fulvio,
Marras Emanuela,
Gariboldi Marzia Bruna,
Sagnella Anna,
Ruani Giampiero,
Zamboni Roberto,
Varchi Greta,
Sotgiu Giovanna
Publication year - 2018
Publication title -
macromolecular materials and engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 96
eISSN - 1439-2054
pISSN - 1438-7492
DOI - 10.1002/mame.201700653
Subject(s) - keratin , materials science , coating , polymerization , surface modification , chemical engineering , reactive oxygen species , photopolymer , nanotechnology , polymer , composite material , chemistry , medicine , biochemistry , pathology , engineering
Mussel‐inspired polydopamine (PD) coating represents a promising route for constructing functional materials and finely tuning or completely changing their surface properties. In this work, a mild and effective method to realize the deposition of PD on keratin‐based films is reported. Reactive oxygen species (ROS), generated by keratin films doped with a photosensitizer, e.g., Azure A (AzA), upon UV–vis and vis‐near IR irradiation, are exploited to obtain the PD coating. Interestingly, the use of vis‐near IR irradiation leads to an increased production of ROS by AzA resulting in a greater PD deposition. Compared to uncoated keratin films, the PD‐keratin coated materials show a granular but homogeneous surface and an increased hydrophilicity, maintaining the ROS generation ability of AzA. This work demonstrates a useful method to effectively and rapidly functionalize with PD materials that are sensitive to temperature, pH and UV light, such as keratin. The proposed strategy allows obtaining new multifunctional biomaterials of potential interest in tissue engineering and drug delivery; in particular, the use of PD‐keratin films for near IR laser bonding of ophthalmic tissue, which is a representative case in wound healing purpose, is shown.