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Facile Fabrication of Mussel‐Inspired Multifunctional Polymeric Membranes with Remarkable Anticoagulant, Antifouling, and Antibacterial Properties
Author(s) -
Shao Mingze,
Wang Rui,
Zhao Weifeng,
Li Jianshu,
Zhao Changsheng
Publication year - 2018
Publication title -
macromolecular materials and engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 96
eISSN - 1439-2054
pISSN - 1438-7492
DOI - 10.1002/mame.201700378
Subject(s) - biofouling , membrane , materials science , methacrylate , chemical engineering , coating , surface modification , polymer chemistry , polymer , polymerization , nanotechnology , chemistry , composite material , biochemistry , engineering
Herein, a facile one‐step surface modification technique of coating functional biopolymer conjugated mussel‐inspired catechol (CA) onto substrate is applied to confer polyethersulfone (PES) membranes with remarkable blood compatibility, antifouling property, and antibacterial property, respectively. CA conjugated poly(2‐acrylamido‐2‐methylpropanesulfonic acid) (PAMPS), poly(sulfobetaine methacrylate) (PSBMA), and poly(methacryloxyethyltrimethyl ammonium chloride) are synthesized via free radical polymerization in the presence of CA, and simultaneously coated onto PES membrane surface. The surface chemical compositions, surface zeta‐potential convince the successful preparation of the modified PES membranes. PAMPS‐coated membrane exhibits excellent blood compatibility, especially anticoagulation property; PSBMA‐coated membrane displays excellent antifouling property and blood compatibility; meanwhile, PDMC‐coated membrane shows robust bactericidal property. In general, this work demonstrates that the mussel‐inspired surface modification protocol provides a facile and versitile method to confer the substrate with excellent blood compatibility, antifouling property, and antibacterial property, respectively, which has great potential for multibiomedical applications, such as blood purification, hemodialysis, and organ implantation.