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Click Crosslinked Chitosan/Gold Nanocomposite Hydrogels
Author(s) -
GarcíaAstrain Clara,
Hernández Rebeca,
Guaresti Olatz,
Fruk Ljiljana,
Mijangos Carmen,
Eceiza Arantxa,
Gabilondo Nagore
Publication year - 2016
Publication title -
macromolecular materials and engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 96
eISSN - 1439-2054
pISSN - 1438-7492
DOI - 10.1002/mame.201600247
Subject(s) - self healing hydrogels , chitosan , nanocomposite , materials science , maleimide , click chemistry , drug delivery , biocompatible material , nanoparticle , nanotechnology , colloidal gold , biosensor , chemical engineering , polymer chemistry , biomedical engineering , medicine , engineering
Preparation of novel nanocomposite hydrogels opens up new avenues to next generation of biocompatible materials to be used in bioengineering and drug delivery. Toward this goal, chitosan nanocomposite hydrogels using click chemistry inspired cross‐linking are prepared. To enable this, Diels–Alder reaction of furan‐containing chitosan and maleimide‐coated gold nanoparticles is employed. The viscoelastic properties of the obtained nanocomposites as well as the effect of the nanoparticles as cross‐linkers are studied, indicating that they play significant role in hydrogel formation and stability. Nanoparticle‐enriched hydrogels are also found to demonstrate pH‐sensitivity therefore showing their potential for future biosensing applications.