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Dual Stimuli Responsive Gelatin‐CNT Hybrid Films as a Versatile Tool for the Delivery of Anionic Drugs
Author(s) -
Cirillo Giuseppe,
Curcio Manuela,
Vittorio Orazio,
Spizzirri Umile Gianfranco,
Nicoletta Fiore Pasquale,
Picci Nevio,
Hampel Silke,
Iemma Francesca
Publication year - 2016
Publication title -
macromolecular materials and engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 96
eISSN - 1439-2054
pISSN - 1438-7492
DOI - 10.1002/mame.201600192
Subject(s) - gelatin , materials science , ketoprofen , polymerization , bovine serum albumin , drug delivery , chemical engineering , carbon nanotube , polymer chemistry , nanotechnology , polymer , composite material , chromatography , organic chemistry , chemistry , engineering
Hybrid hydrogel films able to modulate the release of anionic species, ketoprofen (Ket) and bovine serum albumin (BSA), as a function of their molecular size are prepared by UV‐induced polymerization of methacrylated gelatin in the presence of oxidized multiwalled carbon nanotubes (MWNT_COOH). The dual‐stimuli responsive composites can modulate the release in response to the variation of temperature and the application of an external voltage. Drug release profiles, analyzed by mathematical models, show that different temperatures (25 and 45 °C) and applied voltages (0 and 36 V) have a different effect on the release of the two therapeutics. Ket release is enhanced at 45 °C (77% vs 22% at 25 °C) with the maximum value recorded when 36 V is applied (94%). An increase in the amount of released BSA is recorded at 45 °C (96% vs 50% at 25 °C), while the application of the external voltage reduces this value (39%).