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Making Nonwoven Fibrous Poly(ε‐caprolactone) Constructs for Antimicrobial and Tissue Engineering Applications by Pressurized Melt Gyration
Author(s) -
Xu Zewen,
Mahalingam Sunthar,
Basnett Pooja,
RaimiAbraham Bahijja,
Roy Ipsita,
Craig Duncan,
Edirisinghe Mohan
Publication year - 2016
Publication title -
macromolecular materials and engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 96
eISSN - 1439-2054
pISSN - 1438-7492
DOI - 10.1002/mame.201600116
Subject(s) - materials science , gyration , caprolactone , fiber , composite material , tissue engineering , chemical engineering , morphology (biology) , polymer , polymer chemistry , biomedical engineering , copolymer , mechanical engineering , medicine , engineering , biology , genetics
A pressurized melt gyration process has been used for the first time to generate poly(ε‐caprolactone) (PCL) fibers. Gyration speed, working pressure, and melt temperature are varied and these parameters influence the fiber diameter and the temperature enabled changing the surface morphology of the fibers. Two types of nonwoven PCL fiber constructs are prepared. First, Ag‐doped PCL is studied for antibacterial activity using Gram‐negative Escherichia coli and Pseudomonas aeruginosa microorganisms. The melt temperature used to make these constructs significantly influences antibacterial activity. Neat PCL nonwoven scaffolds are also prepared and their potential for application in muscular tissue engineering is studied with myoblast cells. Results show significant cell attachment, growth, and proliferation of cells on the scaffolds.