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Spatiotemporal Control of Amyloid‐Like Aβ Plaque Formation Using a Multichannel Organic Electronic Device
Author(s) -
Gabrielsson Erik O.,
Armgarth Astrid,
Hammarström Per,
Nilsson K. Peter R.,
Berggren Magnus
Publication year - 2016
Publication title -
macromolecular materials and engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 96
eISSN - 1439-2054
pISSN - 1438-7492
DOI - 10.1002/mame.201500428
Subject(s) - nucleation , fibril , materials science , kinetic control , biophysics , amyloid (mycology) , cluster (spacecraft) , amyloid fibril , senile plaques , chemical physics , nanometre , peptide , chemical engineering , nanotechnology , amyloid β , chemistry , composite material , biochemistry , organic chemistry , computer science , biology , medicine , inorganic chemistry , disease , pathology , alzheimer's disease , engineering , programming language , catalysis
We herein report on an iontronic device to drive and control Aβ1‐40 and Aβ1‐42 fibril formation. This system allows kinetic control of Aβ aggregation by regulation of H + flows. The formed aggregates show both nanometer‐sized fibril structure and microscopic growth, thus mimicking senile plaques, at the H + ‐outlet. Mechanistically we observed initial accumulation of Aβ1‐40 likely driven by electrophoretic migration which preceded nucleation of amyloid structures in the accumulated peptide cluster.