Premium
In Situ Cross‐Linked PNIPAM/Gelatin Nanofibers for Thermo‐Responsive Drug Release
Author(s) -
SlemmingAdamsen Peter,
Song Jie,
Dong Mingdong,
Besenbacher Flemming,
Chen Menglin
Publication year - 2015
Publication title -
macromolecular materials and engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 96
eISSN - 1439-2054
pISSN - 1438-7492
DOI - 10.1002/mame.201500160
Subject(s) - gelatin , materials science , nanofiber , carbodiimide , in situ , swelling , hela , polymer chemistry , chemical engineering , atomic force microscopy , anticancer drug , nanotechnology , drug , composite material , organic chemistry , in vitro , chemistry , biochemistry , pharmacology , engineering , medicine
A simple one‐step approach to generate in situ cross‐linked PNIPAM/gelatin nanofibers has been developed when gelatin and PNIPAM–NHS were electrospun in the presence of the cross‐linking agents 1‐ethyl‐3‐(3‐dimethyl‐aminopropyl)‐1‐carbodiimide hydrochloride (EDC) and N ‐hydroxysuccinimide (NHS). The fibers exhibit the thermo‐responsive swelling/deswelling function, monitored under atomic force microscopy (AFM). When an anti‐cancer drug doxorubincin (DOX) was loaded, the fibers were able to release DOX evidently on demand of a temperature raise and the released DOX could effectively lower the viability of human cervical cancer Hela cells.