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Influence of Drawing on the Antimicrobial and Physical Properties of Chlorhexidine‐Compounded Poly(caprolactone) Monofilaments
Author(s) -
Scaffaro Roberto,
Botta Luigi,
Gallo Giuseppe,
Puglia Anna Maria
Publication year - 2015
Publication title -
macromolecular materials and engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 96
eISSN - 1439-2054
pISSN - 1438-7492
DOI - 10.1002/mame.201500121
Subject(s) - antimicrobial , materials science , caprolactone , chlorhexidine , spinning , antiseptic , kinetics , composite material , chemical engineering , dentistry , chemistry , organic chemistry , polymer , polymerization , medicine , physics , quantum mechanics , engineering
In this work, we prepared poly(caprolactone) (PCL) monofilaments incorporating different amounts of the antiseptic chlorhexidine diacetate (CHX) and evaluated the effect of “online” drawing during the melt spinning or of an “offline” cold drawing on the antimicrobial and physical properties of PCL/CHX monofilaments. The results showed that the drawing conditions strongly affected the properties of the threads. In particular, the filaments exhibited antimicrobial activity for all the draw ratios (DR) adopted, but on increasing DR the antibacterial efficiency reduced. These results were correlated with the CHX surface concentration and with the release kinetics.