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Redox‐ and pH‐Responsive Nanogels Based on Thiolated Poly(aspartic acid)
Author(s) -
Krisch Enikő,
Messager Léa,
Gyarmati Benjámin,
Ravaine Valérie,
Szilágyi András
Publication year - 2016
Publication title -
macromolecular materials and engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 96
eISSN - 1439-2054
pISSN - 1438-7492
DOI - 10.1002/mame.201500119
Subject(s) - miniemulsion , materials science , redox , nanogel , dynamic light scattering , chemical engineering , sonication , fluorescence , transmission electron microscopy , polymer , nanoparticle , drug delivery , polymer chemistry , nanotechnology , polymerization , physics , quantum mechanics , engineering , metallurgy , composite material
Nanogels loaded with fluorescent dextran as a model drug are synthesized by the oxidation induced cross‐linking of water soluble redox responsive thiolated poly(amino acid) in miniemulsion without the introduction of any cross‐linker molecule. Two types of high energy methods, namely, ultrasonication and high pressure homogenization (HPH), are compared. Dynamic light scattering and transmission electron microscopy measurements confirm that spherical nanogels in 100–150 nm diameter range are prepared successfully by HPH method. Size and surface charge of the nanogels can easily be controlled by environmental pH. The release of encapsulated drug is triggered by the degradation of nanogels in reducing environment due to the cleavage of disulphide bonds.