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Reinforcing an Injectable Gelatin Hydrogel with PLLA Microfibers: Two Routes for Short Fiber Production
Author(s) -
PovedaReyes Sara,
MelleraOglialoro Leonardo Rubén,
MartínezHaya Rebeca,
GamboaMartínez Tatiana Carolina,
Gómez Ribelles Jose Luís,
Gallego Ferrer Gloria
Publication year - 2015
Publication title -
macromolecular materials and engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 96
eISSN - 1439-2054
pISSN - 1438-7492
DOI - 10.1002/mame.201500033
Subject(s) - materials science , microfiber , gelatin , composite material , composite number , fiber , fabrication , electrospinning , modulus , polymer , biochemistry , medicine , chemistry , alternative medicine , pathology
Short poly‐ l ‐lactic acid (PLLA) microfibers have been produced in order to disperse them into the gelatin solution and enable injection in the tissue defect prior to gel formation. Two methods for fabrication of loose fibers with submicrometric dimensions are presented in this paper. One is based on manufacturing electrospun meshes and subsequent milling (PLLA‐ES) and the other involves projection of a PLLA solution into a high turbulent non‐solvent medium (PLLA‐HT). Composites produced with PLLA‐ES show a compression Young's modulus from 2.65 kPa for the pure gelatin to 6.69 kPa for the composite with 1.5% PLLA‐ES fibers. The new injectable gelatin–fiber composites are not cytotoxic.