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Remineralization of Demineralized Dentin Induced by Amine‐Terminated PAMAM Dendrimer
Author(s) -
Liang Kunneng,
Yuan He,
Li Jianshu,
Yang Jiaojiao,
Zhou Xin,
He Libang,
Cheng Lei,
Gao Yuan,
Xu Xin,
Zhou Xuedong,
Li Jiyao
Publication year - 2015
Publication title -
macromolecular materials and engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 96
eISSN - 1439-2054
pISSN - 1438-7492
DOI - 10.1002/mame.201400207
Subject(s) - dentin , remineralisation , materials science , tooth remineralization , biomaterial , dendrimer , amine gas treating , demineralization , nuclear chemistry , nanotechnology , polymer chemistry , chemistry , organic chemistry , composite material , enamel paint
The remineralization of demineralized dentin with biomimetic templates is of great interest in the fields of material science and stomatology. Amine‐terminated PAMAM dendrimer (PAMAM‐NH 2 ), which possesses a highly ordered architecture and many calcium coordination sites, may be a desirable template for inducing dentin remineralization. In this study, the remineralization effect of the third generation PAMAM‐NH 2 (G3‐PAMAM‐NH 2 ) on demineralized dentin is investigated. Demineralized dentin samples are treated with G3‐PAMAM‐NH 2 solution (1 mg · mL −1 ), and then immersed in artificial saliva for different periods. The results confirm that G3‐PAMAM‐NH 2 has a good binding capacity to demineralized dentin and can induce needle‐like crystals to precipitate both on the dentin surface and in the dentinal tubules. A good ability of the regenerated minerals to resist acid challenge and good biocompatibility of G3‐PAMAM‐NH 2 are also proved. Overall, the results suggest that G3‐PAMAM‐NH 2 is a promising biomaterial for inducing dentin remineralization.