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Fabrication of Tubular Scaffolds with Controllable Fiber Orientations Using Electrospinning for Tissue Engineering
Author(s) -
Jeong KiYoung,
Paik DongHyun,
Choi SungWook
Publication year - 2014
Publication title -
macromolecular materials and engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 96
eISSN - 1439-2054
pISSN - 1438-7492
DOI - 10.1002/mame.201400178
Subject(s) - materials science , electrospinning , electrical conductor , fiber , composite material , fabrication , tissue engineering , drum , polymer , biomedical engineering , mechanical engineering , medicine , alternative medicine , pathology , engineering
Tubular scaffolds with controllable fiber orientations are fabricated by electrospinning with a conductive rotating drum in the presence of a parallel or orthogonal conductive wire. A higher rotational speed of the drum results in thinner fibers and a more aligned fibrous structure. The fiber orientation can be further precisely controlled by the design of a conductive wire capable of guiding the deposition of electrospun fibers. Parallel or orthogonal fiber orientations in the tubular scaffolds are achieved using an orthogonal or parallel conductive wire, respectively, at a high rotational speed of the drum. Cell culture on the scaffolds with random, parallel, and orthogonal fiber orientations reveals that the degree of stretching of the fibroblast is highly affected by the fiber orientations.