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Solid‐State Properties and Controlled Release of Ranitidine Hydrochloride from Tailored Oxidised Cellulose Beads
Author(s) -
Trygg Jani,
Yildir Emrah,
Kolakovic Ruzica,
Sandler Niklas,
Fardim Pedro
Publication year - 2015
Publication title -
macromolecular materials and engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 96
eISSN - 1439-2054
pISSN - 1438-7492
DOI - 10.1002/mame.201400175
Subject(s) - crystallinity , materials science , swelling , cellulose , chemical engineering , amorphous solid , ranitidine hydrochloride , solid state , polymer , ranitidine , chromatography , nuclear chemistry , organic chemistry , chemistry , composite material , pharmacology , medicine , engineering
Oxidised cellulose beads (anionic groups 0.1–1.85 mmol g −1 ) were loaded with ranitidine HCl. Polymorphic form and crystallinity of the drug was assessed by calorimetric and spectrometric techniques. Release profiles were obtained at physiological conditions and fitted to suitable mathematical models to gain an understanding on release mechanism. Solid‐state analysis showed that the drug was solidified in amorphous form. The amount of drug was uniform and increased with charge of the beads upto loading degree of 25.8%. Release profiles fitted well to the Baker‐Lonsdale's model for non‐swelling system indicating open structure for freely soluble drug. The release was pH independent, providing fast release already at pH 1.2 in simulated gastrointestinal track.