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Generation of PGS / PCL Blend Nanofibrous Scaffolds Mimicking Corneal Stroma Structure
Author(s) -
Salehi Sahar,
Fathi Mohammadhossein,
Javanmard Shaghayegh Haghjooy,
Bahners Thomas,
Gutmann Jochen S.,
Ergün Süleyman,
Steuhl Klaus P.,
Fuchsluger Thomas A.
Publication year - 2014
Publication title -
macromolecular materials and engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 96
eISSN - 1439-2054
pISSN - 1438-7492
DOI - 10.1002/mame.201300187
Subject(s) - materials science , nanofiber , electrospinning , tissue engineering , polyester , wetting , polymer , biomedical engineering , composite material , medicine
Morphological studies of aligned nanofibers scaffolds made of poly(glycerol sebacate)(PGS)/poly( ϵ ‐caprolactone)(PCL) blends for application as corneal tissue scaffolds are presented. Parallel conductive bars are used as ground electrode to generate unidirectional nanofibers. Scaffolds have fibers diameter in the range of 550–300 nm. The structural stability and wettability, especially the in vitro degradation rate, of the electrospun scaffolds can be controlled by regulating the blended ratio of the polymers. The results indicate that PGS/PCL nanofiber scaffolds can be considered as ideal candidates for corneal tissue engineering scaffolds. The particular motivation for this work is to engineer a tissue‐like construct that will mimic the stromal tissue of the cornea.