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Fabrication of Polylactide‐Based Biodegradable Thermoset Scaffolds for Tissue Engineering Applications
Author(s) -
Sakai Reika,
John Baiju,
Okamoto Masami,
Seppälä Jukka V.,
Vaithilingam Jayasheelan,
Hussein Husnah,
Goodridge Ruth
Publication year - 2013
Publication title -
macromolecular materials and engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 96
eISSN - 1439-2054
pISSN - 1438-7492
DOI - 10.1002/mame.201100436
Subject(s) - materials science , biocompatibility , thermosetting polymer , tissue engineering , scaffold , biodegradation , fabrication , thermal stability , polymer , biodegradable polymer , biomedical engineering , composite material , chemical engineering , chemistry , organic chemistry , medicine , alternative medicine , pathology , metallurgy , engineering
The fabrication of tissue engineering scaffolds based on the polymerization of crosslinked polylactide using leaching and batch foaming to generate well‐controlled and interconnected biodegradable polymer scaffolds is reported. The scaffold fabrication parameters are studied in relation to the interpore connectivity, pore morphology, and structural stability of the crosslinked PLA scaffold. In vitro cell culture and in vitro degradation are used to analyze the biocompatibility and biodegradability of the scaffolds. The new crosslinked PLA thermoset scaffolds are highly suitable for bone tissue engineering applications due to their complex internal architecture, thermal stability, and biocompatibility.