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Clay Nanotube/Poly(methyl methacrylate) Bone Cement Composites with Sustained Antibiotic Release
Author(s) -
Wei Wenbo,
Abdullayev Elshad,
Hollister Anne,
Mills David,
Lvov Yuri M.
Publication year - 2012
Publication title -
macromolecular materials and engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 96
eISSN - 1439-2054
pISSN - 1438-7492
DOI - 10.1002/mame.201100309
Subject(s) - halloysite , materials science , gentamicin sulfate , bone cement , composite material , cement , ultimate tensile strength , methyl methacrylate , nanotube , monomer , polymer , gentamicin , antibiotics , carbon nanotube , microbiology and biotechnology , biology
Orthopedic‐grade PMMA bone cement, admixed with prophylactic antibiotics, is widely used in hip and knee replacement surgery. There is a critical need to improve its structural integrity and to control antibiotic release. In this study, clay nanotubes are loaded with the antibiotic gentamicin sulfate and the cement is doped with 5–8 wt% nanotubes. The halloysite nanotubes isolate the drug from the cement monomers and serve as nanocontainers for sustained release of the antibiotic. Gentamicin‐loaded clay nanotubes admixed in PMMA cement provide sustained release up to 300–400 h and with enhanced release at cement cracks. The PMMA/halloysite/gentamicin composite tensile strength does not deteriorate as compared with pure cement and its adhesion to bone is significantly increased.