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Synthesis and Drug‐Delivery Behavior of Chitosan‐Functionalized Graphene Oxide Hybrid Nanosheets
Author(s) -
Rana Vijay Kumar,
Choi MyeonCheon,
Kong JinYeon,
Kim Gwang Yeon,
Kim Mi Ju,
Kim SunHee,
Mishra Satyendra,
Singh Raj Pal,
Ha ChangSik
Publication year - 2011
Publication title -
macromolecular materials and engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 96
eISSN - 1439-2054
pISSN - 1438-7492
DOI - 10.1002/mame.201000307
Subject(s) - graphene , materials science , chitosan , exfoliation joint , x ray photoelectron spectroscopy , raman spectroscopy , oxide , chemical engineering , drug delivery , aqueous solution , solubility , hybrid material , nanotechnology , organic chemistry , chemistry , physics , optics , engineering , metallurgy
Chitosan‐functionalized graphene oxides (FGOCs) were successfully synthesized. FGOCs were found to significantly improve the solubility of the GO in aqueous acidic media. The presence of organic groups was confirmed by means of XPS and TGA. Restoration of the sp 2 carbon network and exfoliation of graphene sheets were confirmed by Raman spectroscopy, UV‐visible spectroscopy and WAXD. The SEM and AFM investigations of the resultant FGOCs showed that most of the graphene sheets were individual and few were layered. Controlled release behavior of Ibuprofen and 5‐fluorouracil was then investigated. We found that FGOCs are a promising new material for biological and medical applications.