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One‐Step Immobilization of Protein‐Encapsulated Core/Shell Particles onto Nanofibers
Author(s) -
Park Chul Ho,
Lee Jonghwi
Publication year - 2010
Publication title -
macromolecular materials and engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 96
eISSN - 1439-2054
pISSN - 1438-7492
DOI - 10.1002/mame.201000039
Subject(s) - materials science , nanofiber , nanocomposite , polymer , porosity , chemical engineering , lactic acid , glycolic acid , nanoparticle , nanotechnology , composite material , biology , bacteria , engineering , genetics
A novel method is described to functionalize nanofibers to form a nanocomposite with core/shell particles in order to control protein release. The nanocomposite is produced by electrically neutralizing negatively charged poly(lactic acid) nanofibers with positively charged poly[(lactic acid)‐ co ‐(glycolic acid)] particles via a one‐step electrohydrodynamic jetting process. The protein‐encapsulated core/shell particles exhibited no significant initial burst release or denaturation. The protein release profile was controlled by porosity and protein/polymer interactions. The method may be promising to engineer intelligent scaffolds that can fulfill the needs of biomimetic materials.