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Characterization of Low‐Molecular‐Weight PLA using HPLC
Author(s) -
Codari Fabio,
Moscatelli Davide,
Storti Giuseppe,
Morbidelli Massimo
Publication year - 2010
Publication title -
macromolecular materials and engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 96
eISSN - 1439-2054
pISSN - 1438-7492
DOI - 10.1002/mame.200900172
Subject(s) - high performance liquid chromatography , oligomer , materials science , condensation polymer , aqueous solution , characterization (materials science) , chromatography , titration , analytical chemistry (journal) , polymer chemistry , chemistry , organic chemistry , polymer , composite material , nanotechnology
HPLC is applied and assessed as an effective tool to investigate both the production of PLA by polycondensation and its corresponding degradation. A new HPLC calibration procedure, through which it is possible to fully characterize LMW PLA samples by determining the concentration of each individual oligomer, is developed. A comparison between HPLC, 1 H NMR spectroscopy and non‐aqueous solution titration is also reported in order to confirm the reliability of the proposed method. Finally, the proposed analytical technique is applied to monitor the development of a polycondensation reaction performed at 150 °C and 133.3 mbar for 12 h.