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Mechanical Properties and Antimicrobial Activity of Silicone Rubber Compounds Containing Acrylated Norfloxacin and Its Polymer
Author(s) -
Yang HeaSun,
Park EunSoo
Publication year - 2006
Publication title -
macromolecular materials and engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 96
eISSN - 1439-2054
pISSN - 1438-7492
DOI - 10.1002/mame.200500427
Subject(s) - curing (chemistry) , antimicrobial , norfloxacin , materials science , silicone , peroxide , silicone rubber , ultimate tensile strength , nuclear chemistry , chemistry , polymer chemistry , organic chemistry , composite material , antibiotics , biochemistry , ciprofloxacin
Summary: Antibacterial silicone rubbers (SR) were prepared by platinum curing and peroxide curing of a silicone compound containing the synthetic antimicrobial monomer 1‐ethyl‐6‐fluoro‐7‐{4‐[2‐hydroxy‐3‐(2‐methylacryloyloxy)‐propyl]piperazin‐1‐yl}‐4‐oxo‐1,4‐dihyroquinoline‐3‐carboxylic acid (MQ) and its polymer PMQ. The effects of the two curing systems on the mechanical properties were compared. Tensile strength and elongation at break of the platinum‐cured SR decreased with increasing concentrations of MQ and PMQ. For the peroxide curing system, the elongation at break increased with increasing concentrations of the antimicrobial agents. The antibacterial activity of the prepared SR was examined by the shake flask test against Staphylococcus aureus and Escherichia coli , which are representative of Gram‐positive and Gram‐negative bacteria, respectively. All compounds showed excellent antibacterial activities against these two types of bacteria.Structure of acrylated norfloxacin.