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Cryogel Carriers Comprising β‐Cyclodextrin Moieties for Improved Solubilization and Delivery of Aripiprazole
Author(s) -
Danov Yavor,
Georgieva Dilyana,
Mihaylova Rositsa,
Kostova Bistra,
Petrov Petar D.
Publication year - 2021
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.202100004
Subject(s) - aripiprazole , chemistry , cyclodextrin , drug delivery , drug carrier , aqueous solution , solubilization , solubility , tautomer , polymer chemistry , combinatorial chemistry , schizophrenia (object oriented programming) , organic chemistry , biochemistry , computer science , programming language
Abstract Aripiprazole is a second‐generation atypical antipsychotic used for the treatment of schizophrenia, bipolar disorder, tic disorders, major depressive disorder, etc. However, aripiprazole is poorly soluble in water and many efforts are focused on developing delivery systems which can improve the solubility and the therapeutic activity of aripiprazole. In this contribution, the fabrication of novel cryogel carriers comprising β‐cyclodextrin (β‐CD) moieties for improved solubilization of aripiprazole is reported. Cryogels are synthesized by photochemical crosslinking of N , N ‐dimethylacrylamide (DMA) and β‐CD triacrylate (β‐CD‐Ac 3 ) in frozen aqueous system using H 2 O 2 as initiator. The effect of DMA/β‐CD‐Ac 3 mass ratio on the reaction efficiency, physico‐mechanical properties of cryogel, and drug loading efficiency is evaluated. The cryogel carriers are loaded with aripiprazole via procedure favoring inclusion of drug molecules into the hydrophobic cavity of β‐CD. The release of aripiprazole from PDMA/β‐CD carriers at pH 1.2 and 6.8 is studied and compared to the pure PDMA carriers.