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Rational Optimization of the Petasis Three‐Component Reaction as a Feasible Elementary Reaction in Polymer Chemistry
Author(s) -
Takahashi Ryo,
Kakuchi Ryohei
Publication year - 2021
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.202000347
Subject(s) - chemistry , glyoxylic acid , polymer , component (thermodynamics) , boronic acid , combinatorial chemistry , organic chemistry , physics , thermodynamics
In this research, the Petasis three‐component reaction (Petasis‐3CR) among aromatic boronic acids, amines, and glyoxylic acids is feasibly optimized to seek integration with polymer synthesis. The Petasis‐3CR is expanded using protected boronic acids, bypassing the disadvantages of the polymers featuring boronic acids. Based on the modification, the Petasis‐3CR is now highly compatible with synthetic polymer chemistry, yielding poly (α‐amino acids), which are otherwise difficult to synthesize.