Premium
Facile Synthesis of Novel Thermo‐Responsive Polyvalerolactones with Tunable LCSTs
Author(s) -
Yiu Asteria,
Simchuk Daniel,
Hao Jing
Publication year - 2020
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.202000136
Subject(s) - thermoresponsive polymers in chromatography , biocompatible material , polymer , lower critical solution temperature , polymer chemistry , polymerization , thiol , materials science , chemistry , chemical engineering , organic chemistry , copolymer , biomedical engineering , phase (matter) , engineering , medicine , reversed phase chromatography
Thermoresponsive polymers have emerged as promising candidates for biomedical applications. Seven novel oligoethylene glycol (OEG) functionalized polyvalerolactones P1–P7 are synthesized from poly(α‐allyl‐δ‐valerolactone) via thiol‐ene addition post‐polymerization modification. All seven polymers exhibit thermoresponsive behavior with lower critical solution temperatures (LCSTs) ranging from 13.8 to 92.2 °C. Polymers P5–P7 are synthesized via thiol‐ene addition reaction using two thiol mixtures at three different ratios. LCSTs of P5–P7 fall in between those of P1 and P2 , and exhibit a linear relationship, indicating a tunable thermoresponsive system. This newly developed system offers great control for a desired thermoresponsive biocompatible, biodegradable polymeric system with desired LCSTs.