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pH‐Responsive Micelle‐Forming Amphiphilic Triblock Copolymers
Author(s) -
Bener Semira,
Puglisi Antonino,
Yagci Yusuf
Publication year - 2020
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.202000109
Subject(s) - ethylene glycol , copolymer , micelle , amphiphile , polymer , chemistry , polydimethylsiloxane , nanoparticle , gel permeation chromatography , polymer chemistry , peg ratio , chemical engineering , organic chemistry , materials science , nanotechnology , aqueous solution , engineering , finance , economics
A novel pH‐responsive micellar nanoparticle based on poly(ethylene glycol)–polydimethylsiloxane–poly(ethylene glycol) triblock copolymer with benzoic imine linkage is reported. A new synthetic approach to produce the pH‐cleavable polymer that can self‐assemble into stable micellar nanoparticle is presented. Such nanoparticles are stable at physiological pH, but degrade at slightly acidic pH, making this system potentially suitable to exploit pH gradients in biological compartments. The precursors, intermediates, final polymers, and micellar nanoparticles are characterized in detail by various spectroscopic techniques, gel permeation chromatography, and particle size measurements.