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Synthesis of Riboflavin‐Based Macromolecules through Low ppm ATRP in Aqueous Media
Author(s) -
Zaborniak Izabela,
Chmielarz Paweł,
Matyjaszewski Krzysztof
Publication year - 2020
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201900496
Subject(s) - polymer chemistry , atom transfer radical polymerization , copolymer , chemistry , acrylate , dispersity , radical polymerization , polymer , reversible addition−fragmentation chain transfer polymerization , methacrylate , aqueous solution , ethylene glycol , organic chemistry
A vitamin‐B 2 ‐based macroinitiator is prepared by esterification of riboflavin with 2‐bromoisobutyryl bromide. Following the “core first” methodology, “phoenix”‐shape (co)polymers with a polar riboflavin core and either a hydrophobic (poly( n ‐butyl acrylate) or poly(methyl methacrylate)) or hydrophilic (poly( N ‐isopropylacrylamide)‐ block ‐poly(oligo(ethylene glycol) acrylate) or poly( N ‐isopropylacrylamide)‐ block ‐poly(2‐hydroxyethyl acrylate)) tails are synthesized via low ppm atom transfer radical polymerization procedures. Polymers have predetermined molecular weights and a low dispersity ( Ð < 1.2). 1 H NMR analysis confirms the successful formation of targeted (co)polymers with the preserved riboflavin functionality.