Premium
Determination of the Binding Situation of Pyridine in Xylan Sulfates by Means of Detailed NMR Studies
Author(s) -
Gabriel Lars,
Günther Wolfgang,
Pielenz Friederike,
Heinze Thomas
Publication year - 2020
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201900327
Subject(s) - pyridine , chemistry , sulfation , xylan , organic chemistry , polymer chemistry , carbon 13 nmr , proton nmr , polysaccharide , biochemistry
Xylan sulfate is an important drug to treat interstitial cystitis. Production of the drug by sulfation of the polysaccharide with a sulfating agent like chlorosulfuric acid and pyridine–SO 3 complex in pyridine may lead to products containing pyridine‐based impurities. Xylan sulfate containing nitrogen is investigated by different NMR measurements in order to clarify the binding situation of pyridine. The detailed NMR studies allow the conclusion that the pyridine‐based impurities are covalently bonded to the reducing end group. Furthermore, the NMR spectroscopic investigation indicates that the side reactions occur at shorter polymer chains only.