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Preparation and Characterization of Novel Low‐Temperature/pH Dual‐Responsive Poly( N ‐isopropylacrylamide‐ co ‐1 H ‐benzimidazolyl‐ethyl acrylate) Copolymers
Author(s) -
Zhang ShuGui,
Ju XiaoJie,
Zhou XingLong,
Pu XingQun,
Peng HanYu,
Wang Wei,
Xie Rui,
Liu Zhuang,
Chu LiangYin
Publication year - 2019
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201900123
Subject(s) - copolymer , polymer chemistry , chemistry , lower critical solution temperature , acrylate , poly(n isopropylacrylamide) , polymer , benzimidazole , ethyl acrylate , organic chemistry
Stimuli‐responsive polymers in response to both low temperature and pH are of great potential for designing drug carriers to obtain a better therapeutic effect during cryotherapy of tumors. In this work, novel low‐temperature and pH dual‐responsive poly( N ‐isopropylacrylamide‐ co ‐1 H ‐benzimidazolyl‐ethyl acrylate) (PNBM) linear copolymers are developed, which can undergo stretching/shrinking conformational transition at low temperature and mildly acidic conditions. The dual‐responsive properties of PNBM copolymers can be affected and regulated by the host–guest inclusion action between benzimidazole and hydroxypropyl‐β‐cyclodextrin (HP‐β‐CD) molecules. The critical response temperature of the copolymers can be flexibly adjusted when the benzimidazole groups in copolymer chains are captured by HP‐β‐CD. And the PNBM copolymers present a pH‐responsive stretching‐to‐shrinking‐to‐stretching conformational transition in a narrow pH range in HP‐β‐CD solution. The results provide valuable guidance for designing and applying PNBM‐based smart materials in biomedical applications.