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Facile Synthesis of a Carnosine‐Pendent Cationic Polymer via Free Radical Polymerization and Application in Gene Delivery
Author(s) -
Cao Leilei,
Li Xiao,
Wu Tiantian,
Cai Xuetong,
Zhang Yajie,
Ji Jinkai,
Zhang Xiaoran,
Gao Yajing,
Feng Fude
Publication year - 2019
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201900049
Subject(s) - methacrylamide , cationic polymerization , chemistry , polymer chemistry , polymer , gene delivery , monomer , polymerization , radical polymerization , carnosine , trifluoroacetic acid , self healing hydrogels , combinatorial chemistry , organic chemistry , biochemistry , acrylamide , transfection , gene
l ‐carnosine is a bipeptide with varieties of biomedical benefits, but rarely reported as a component in structurally defined polymers due to the unavailability of isolatable monomers. In this report, a simple method to synthesize a carnosine‐derived methacrylamide in three steps is established and a neutral polymer with a narrow molecular weight distribution ( M n 7.6 kDa, Ð 1.2) and high structural regularity is prepared via free radical polymerization, and a carnosine‐pendent cationic homopolymer is finally achieved after trifluoroacetic acid‐mediated deprotection without a concern of impurities such as metals. The antioxidative activity, cytotoxicity, DNA‐binding capability, and gene delivery performance of the cationic polymer are also studied.