z-logo
Premium
Direct Metal‐Free Preparation of Functionalizable Polylactic Acid‐Ethisterone Conjugates in a One‐Pot Approach
Author(s) -
Luo ShiHe,
Wu YanCheng,
Cao Liang,
Lin JianYun,
Gao Jian,
Chen ShuiXia,
Wang ZhaoYang
Publication year - 2019
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201800475
Subject(s) - polylactic acid , biopolymer , conjugate , surface modification , drug delivery , condensation polymer , polymer chemistry , chemistry , click chemistry , combinatorial chemistry , organic chemistry , polymer , mathematical analysis , mathematics
A series of polylactic acid (PLA) conjugates (PLA‐ES) are synthesized via direct melt polycondensation (DMP) of lactic acid (LA) with ethisterone (ES) in the presence of 0.3 wt% toluenesulfonic acid at 160 °C for 6 h. The drug content of PLA conjugates can be simply adjustable. Further functionalization via Click chemistry is also achieved to extend the biomedicine application of biopolymer based drug delivery.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here