Premium
Direct Metal‐Free Preparation of Functionalizable Polylactic Acid‐Ethisterone Conjugates in a One‐Pot Approach
Author(s) -
Luo ShiHe,
Wu YanCheng,
Cao Liang,
Lin JianYun,
Gao Jian,
Chen ShuiXia,
Wang ZhaoYang
Publication year - 2019
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201800475
Subject(s) - polylactic acid , biopolymer , conjugate , surface modification , drug delivery , condensation polymer , polymer chemistry , chemistry , click chemistry , combinatorial chemistry , organic chemistry , polymer , mathematical analysis , mathematics
A series of polylactic acid (PLA) conjugates (PLA‐ES) are synthesized via direct melt polycondensation (DMP) of lactic acid (LA) with ethisterone (ES) in the presence of 0.3 wt% toluenesulfonic acid at 160 °C for 6 h. The drug content of PLA conjugates can be simply adjustable. Further functionalization via Click chemistry is also achieved to extend the biomedicine application of biopolymer based drug delivery.