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Layer‐By‐Layer Modified Superparamagnetic Iron Oxide Nanoparticles with Stimuli‐Responsive Drug Release Properties
Author(s) -
Akbar Majid,
Cagli Eda,
ErelGöktepe Irem
Publication year - 2019
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201800422
Subject(s) - layer by layer , superparamagnetism , nanoparticle , polymer , coprecipitation , tannic acid , chemical engineering , coating , chemistry , drug delivery , peptization , materials science , polymer chemistry , layer (electronics) , nanotechnology , nuclear chemistry , organic chemistry , magnetization , physics , quantum mechanics , magnetic field , engineering
Superparamagnetic iron oxide nanoparticles (SPIONs) are synthesized through ultrasound based coprecipitation method. SPIONs are coated with poly(2‐isopropyl‐2‐oxazoline) (PIPOX) and tannic acid (TA) in a layer‐by‐layer (LbL) fashion at pH 4 and 25 °C. PIPOX/TA coated SPIONs are then loaded with doxorubicin (DOX) at pH 7.5 and 25 °C. DOX release from LbL‐coated SPIONs is examined at pH 7.5 and pH 6 at 25 °C, 37 °C, and 42 °C. LbL‐coated SPIONs exhibit dual responsive behavior and release the greatest amount of DOX at pH 6 and 42 °C. Increasing layer number decreases the colloidal stability and saturation magnetization. Superparamagnetic behavior of SPIONs retains after coating. Overall, this study shows an alternative strategy to modify the surface of SPIONs with a dual responsive polymer coating which is capable of releasing DOX at moderately acidic pH of 6 within a physiologically related temperature range. Besides, it generates fundamental knowledge for further development of SPIONs‐based drug carriers.