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Poly(hydroxy acid) Nanoparticles for the Encapsulation and Controlled Release of Doxorubicin
Author(s) -
Khuphe Mthulisi,
Thornton Paul D.
Publication year - 2018
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201800352
Subject(s) - amphiphile , copolymer , polymer chemistry , chemistry , nanoparticle , polymerization , aqueous solution , doxorubicin , phenylalanine , ring opening polymerization , polymer , materials science , organic chemistry , nanotechnology , amino acid , biochemistry , medicine , surgery , chemotherapy
Diblock poly(hydroxy acid) copolymers are created by the sequential ring‐opening polymerization of l ‐phenylalanine O‐carboxyanhydride and l ‐lysine(carboxybenzyl) O‐carboxyanhydride, and l ‐phenylalanine O‐carboxyanhydride and γ ‐benzyl l ‐glutamic acid O‐carboxyanhydride. Upon protecting group removal, two amphiphilic block copolymers are formed that can self‐organize in aqueous solution to form spherical nanoparticles. Such nanoparticles are capable of encapsulating doxorubicin before allowing its programmed payload release upon incubation within acidic solution. Consequently, the reported biodegradable materials are highly promising candidates for deployment for the transport and programmed release of chemotherapeutics to acidic environments, such as cancerous tissue.