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Sugar‐Derived Poly(β‐thioester)s as a Biomedical Scaffold
Author(s) -
Moon Nicholas G.,
Mazzini Fiorella,
Pekkanen Allison M.,
Wilts Emily M.,
Long Timothy E.
Publication year - 2018
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201800177
Subject(s) - polymer , differential scanning calorimetry , polymer chemistry , fourier transform infrared spectroscopy , monomer , glass transition , materials science , dynamic mechanical analysis , isosorbide , comonomer , chemical engineering , chemistry , composite material , organic chemistry , physics , engineering , thermodynamics
Abstract The monomer isosorbide diacrylate ( i SDA) and commercially available dithiols allowed access to a range of biosourced, degradable polymers. Altering the dithiol identity significantly affected the glass transition T g s of the polymer products; however, polymers did not exhibit T g s above room temperature. Incorporating the comonomer N,N ′‐methylene bisacrylamide provided mechanical reinforcement through hydrogen bonding, resulting in soft, pliable materials. Differential scannin calorimetry (DSC) and variable‐temperature fourier‐transform infrared (FTIR) spectroscopy indicated that increases in mechanical integrity resulted from hydrogen bonding. Dynamic mechanical analysis (DMA) revealed materials that exhibited suitable moduli and service windows at body temperature. Biological evaluation demonstrated favorable cytotoxicity and cell attachment, rendering these materials potential candidates as novel scaffold materials for tissue growth.