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Tuned Surface and Mechanical Properties of Polymeric Film Prepared by Random Copolymers Consisting of Methacrylate‐POSS and 2‐(Methacryloyloxy)ethyl Phosphorylcholine
Author(s) -
Chatterjee Suchismita,
Matsumoto Takuya,
Nishino Takashi,
Ooya Tooru
Publication year - 2018
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201700572
Subject(s) - methacrylate , copolymer , silsesquioxane , polymer chemistry , phosphorylcholine , materials science , polymer , moiety , monomer , contact angle , polymerization , radical polymerization , surface modification , chemical engineering , chemistry , organic chemistry , composite material , biochemistry , engineering
Poly(2‐(methacryloyloxy)ethyl phosphorylcholine) (PMPC) is known as a biocompatible polymers. Copolymerization of 2‐(methacryloyloxy)ethyl phosphorylcholine (MPC) and hydrophobic monomers is a general approach that gives bioinert functions to solid materials via the surface coating. However, due to the amorphous nature and super hydrophilicity of the MPC‐based copolymers, both the surface and the mechanical properties are not controlled for biomedical applications. Here, the modulated mechanical property and the surface wettability of the MPC‐based copolymers are shown by using a polyhedral oligomeric silsesquioxane (POSS) methacrylate. MPC is copolymerized with POSS methacrylates bearing different vertex groups of ethyl (C 2 H 5 ), hexayl (C 6 H 13 ), and octayl (C 8 H 17 ) via radical polymerization. It is found that only the C 2 H 5 ‐POSS induces the increased mechanical strength, low surface wettability, and cellular attachment, suggesting that the C 2 H 5 ‐POSS moiety restricts the motion of PMPC chain. The finding is anticipated to be tuned for both surface and bulk functions of PMPC for biomedical applications.