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Incorporation of Magnetic Nanoparticles in Poly(Methyl Methacrylate) Nanocapsules
Author(s) -
Ronco Ludmila I.,
Feuser Paulo E.,
da Cas Viegas Alexandre,
Minari Roque J.,
Gugliotta Luis M.,
Sayer Claudia,
Araújo Pedro H. H.
Publication year - 2018
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201700424
Subject(s) - miniemulsion , nanocapsules , polymer chemistry , polymerization , nanoparticle , polymer , magnetic nanoparticles , materials science , radical polymerization , chemical engineering , methyl methacrylate , oleic acid , chemistry , poly(methyl methacrylate) , organic chemistry , nanotechnology , biochemistry , engineering
Magnetic nanoparticles (MNPs) encapsulated in polymeric systems are promising materials for hyperthermia treatments and targeting drug delivery in cancer therapy. To improve the encapsulation efficiency of therapeutic drugs, high amounts of fatty acids can be incorporated into the polymer matrix. The effect of the monounsaturated fatty acid oleic acid (OA)/Crodamol (triacylglycerol of saturated fatty acids) ratio in the incorporation of MNPs in poly(methyl methacrylate) (PMMA) nanocapsules by miniemulsion polymerization is investigated. The OA/Crodamol ratio affects polymerization kinetics, polymer microstructure, and nanocapsules morphology. Furthermore, MNPs are efficiently encapsulated in PMMA nanocapsules with high Crodamol content while preserving their super‐paramagnetic behavior with considerable magnetization saturation values.