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Photo‐Decomposable Sub‐Micrometer Albumin Particles Cross‐Linked by ortho ‐Nitrobenzyl Derivatives
Author(s) -
Li Huiying,
Xiong Yu,
Zhang Yixian,
Tong Weijun,
Georgieva Radostina,
Bäumler Hans,
Gao Changyou
Publication year - 2017
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201700413
Subject(s) - bovine serum albumin , chemistry , micrometer , polymer chemistry , macromolecule , bromide , amine gas treating , molecule , combinatorial chemistry , organic chemistry , chromatography , biochemistry , physics , optics
Stimuli‐responsive particles are widely used as carriers for on‐demand delivery of drugs, genes, proteins, etc., due to their response to environmental stimuli. In this study, photoresponsive albumin sub‐micrometer particles are fabricated by using ortho ‐nitrobenzyl derivative 4‐bromomethyl‐3‐nitrobenzoic acid (BNBA) as a cross‐linker. Bovine serum albumin (BSA)‐doped MnCO 3 particles are used as the sacrificial template, in which the BSA molecules are cross‐linked by BNBA under the activation of 4‐(4,6‐dimethoxy‐1,3,5‐triazin‐2‐yl)‐4‐methylmorpholinium chloride. After removal of MnCO 3 particles by ethylene diamine tetraacetic acid, photoresponsive BSA–BNBA sub‐micrometer particles are obtained. Since the CN bond formed via reaction of benzyl bromide and amine is photocleavable, the particles can be decomposed upon UV irradiation at 365 nm under acidic environment. The loaded macromolecules can be released upon UV irradiation, exhibiting great potential applications of the particles in the field of controlled release.