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Thermoresponsive Polypeptoid‐Coated Superparamagnetic Iron Oxide Nanoparticles by Surface‐Initiated Polymerization
Author(s) -
Kurzhals Steffen,
Pretzner Barbara,
Reimhult Erik,
Zirbs Ronald
Publication year - 2017
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201700116
Subject(s) - superparamagnetism , dispersity , polymerization , nanoparticle , polymer , materials science , magnetic nanoparticles , chemical engineering , iron oxide nanoparticles , colloid , polymer chemistry , thermoresponsive polymers in chromatography , surface modification , nanotechnology , chemistry , organic chemistry , magnetization , phase (matter) , composite material , physics , quantum mechanics , magnetic field , engineering , reversed phase chromatography
Thermoresponsive polypeptoids are promising candidates for medical applications due to their biomimetic properties. When such polymers are grafted on magnetic nanoparticles, materials can be obtained that combine a temperature‐triggered solubility transition with magnetic extraction. The synthesis of monodisperse, superparamagnetic iron oxide nanoparticles is described with densely surface‐grafted polypeptoid shells that have tunable thermoresponsive colloidal stability. The synthesis combines ligand exchange with controlled surface‐initiated polymerization of N ‐substituted N ‐carboxyanhydrides for the preparation of well‐defined core–shell nanoparticles.