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Novel Fluorinated Polymer‐Mediated Upconversion Nanoclusters for pH/Redox Triggered Anticancer Drug Release and Intracellular Imaging
Author(s) -
Yan Kai,
Yu Jiani,
Zhang Bingbo,
Wu Limin
Publication year - 2017
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201700090
Subject(s) - nanoclusters , ethylene glycol , amphiphile , copolymer , chemistry , polymer chemistry , biocompatibility , methacrylate , photon upconversion , photochemistry , micelle , polymerization , redox , polymer , combinatorial chemistry , materials science , organic chemistry , aqueous solution , ion
This paper designs and synthesizes a novel amphiphilic fluorinated block copolymer, composed of oligo ethylene glycol methyl ether methacrylate, 2‐( N , N ‐dimethylamino)ethyl methacrylate, and developing 2‐((2‐methacryloyloxy ethyl) disulfanyl) ethyl 3,5‐bis(trifluoromethyl) benzoate, by reversible addition–fragmentation chain transfer polymerization. This amphiphilic block copolymer can self‐assemble with hydrophobic lanthanide‐based upconversion nanoparticles to form hybrid colloidal nanoclusters. The obtained nanoclusters exhibit not only good water‐dispersibility, high biocompatibility, and strong stability in biological milieu, but excellent pH/redox‐dual‐responsive release in vitro behavior for doxorubicin (DOX). And the DOX‐loaded nanoclusters have much better therapeutic effect than free DOX and can be uptaken by MCF‐7 cells with evident upconversion luminescence signal for intracellular imaging.