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Au Nanoparticle‐Corona Loaded Polystyrene‐ b ‐Quaternized Poly(2‐vinylpyridine) Micelles and their Interaction with DNA
Author(s) -
Papagiannopoulos Aristeidis,
Mousdis George,
Pispas Stergios
Publication year - 2017
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201600439
Subject(s) - micelle , nanocarriers , dynamic light scattering , hydrodynamic radius , fluorescence , polystyrene , nanoparticle , copolymer , aqueous solution , chemistry , dna , population , polymer chemistry , chemical engineering , materials science , nanotechnology , polymer , organic chemistry , optics , biochemistry , physics , demography , engineering , sociology
The incorporation of Au nanoparticles to polystyrene‐ b ‐quaternized poly(2‐vinylpyridine) (SQVP) micelles and their interaction with DNA in aqueous solutions is investigated. Micelles of a well‐defined single population in solution keep their size while AuNPs appear to bind near their core, as observed by static and dynamic light scattering. The apparent molecular weight increases as a function of Au concentration, which proves controllable NP loading. Au‐loaded SQVP micelles create complexes with DNA where the micelles still preserve their morphology and size. The fluorescence intensity from SQVP‐Au aggregates drops as Au accumulates on the micelles. The fluorescence spectrum remains practically unaffected by the addition of DNA. SQVP micelles offer a stable and well‐defined template for the formulation of drug and DNA nanocarriers as hierarchically self‐assembled hybrid nanostructured functional materials.