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Kinetic Analysis of Molecular Permeabilities of Free‐Standing Polysaccharide Composite Films
Author(s) -
Iijima Kazutoshi,
Kimura Takayuki,
Sato Ryo,
Takahashi Tomoki,
Hashizume Mineo
Publication year - 2017
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201600391
Subject(s) - chemistry , permeation , ionic strength , partition coefficient , chitosan , permeability (electromagnetism) , methylene blue , polysaccharide , diffusion , ionic bonding , methylene , chromatography , chemical engineering , analytical chemistry (journal) , polymer chemistry , organic chemistry , thermodynamics , aqueous solution , membrane , ion , biochemistry , physics , photocatalysis , engineering , catalysis
This study is performed in order to assess the molecular permeabilities of composite films of chondroitin sulfate C (CS) and chitosan (CHI) prepared by the hot press technique. Permeation behaviors are evaluated using horizontal diffusion cells and four substrates with different charges: methylene blue (MB), orange II (OR), l ‐tryptophan (Trp), and 4‐methylumbelliferyl β‐ d ‐galactopyranoside (MUG). Permeability coefficients, diffusion coefficients, and partition coefficients are calculated from permeation curves. When MB and OR are used as the permeants, permeability coefficients in solutions with higher pH or ionic strength are greater than in those with lower pH or ionic strength. Permeability coefficients at pH 5.9 at which Trp carries zero net charge are as follows: Trp > MB ≈ MUG > OR. The diffusion coefficients and partition coefficients obtained indicate that CS/CHI films permeate these molecules based on a partition mechanism at lower pH and a pore model at higher pH. These characteristics appear to reflect the unique microenvironment of films consisting of polyion complexes of oppositely charged polysaccharides.