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A pH‐Sensitive Phospholipid Polymeric Prodrug Based on Branched Polyethylenimine for Intracellular Drug Delivery
Author(s) -
Wang Haibo,
Xiong Junjie,
Liu Gongyan,
Wang Yunbing
Publication year - 2016
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201600261
Subject(s) - prodrug , polyethylenimine , micelle , chemistry , amphiphile , drug delivery , cytotoxicity , doxorubicin , hela , biophysics , aqueous solution , combinatorial chemistry , copolymer , in vitro , organic chemistry , biochemistry , polymer , chemotherapy , transfection , medicine , gene , surgery , biology
A biomimic pH‐sensitive polymeric prodrug based on branched polyethylenimine‐ graft ‐12‐acryloyloxy dodecyl phosphorylcholine and 6‐maleimidocaproyl‐doxorubicin is rationally designed and successfully synthesized. This polymeric prodrug can spontaneously self‐assemble into spherical nanostructures in aqueous solution. The in vitro drug release results imply that this polymeric prodrug can maintain stable in blood circulation while enhance drug release at endosomal acidic condition. Fluorescence microscopy and flow cytometry results demonstrate that the formed prodrug micelles can be internalized by cancer cells effectively. More importantly, this prodrug exhibits excellent cytotoxicity against Hela cells, indicating the pH‐sensitive polymeric prodrug micelles can potentially work as a promising platform for efficient cancer therapy.