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Redox and pH Dual‐Responsive Supramolecular Micelles with a Traditional Polymer Block and a Supramolecular Block for Drug Controlled Release
Author(s) -
Zhang Xiaojin,
Zhuo Renxi
Publication year - 2016
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201600172
Subject(s) - micelle , supramolecular chemistry , chemistry , adamantane , cyclodextrin , supramolecular polymers , redox , ferrocene , ethylene glycol , polymer chemistry , supramolecular assembly , combinatorial chemistry , organic chemistry , aqueous solution , crystal structure , electrochemistry , electrode
Redox and pH dual‐responsive supramolecular micelles are prepared through a traditional polymer block and a supramolecular block to completely release the drugs. Ferrocene‐introduced and hydrophobic‐modified β ‐cyclodextrin ( β ‐CD‐Fc‐Ace, where β ‐CD, Fc, and Ace refer to β ‐cyclodextrin, ferrocene, and acetal, respectively) is used to build the supramolecular block. Adamantane‐terminated poly(ethylene glycol) methyl ether (mPEG‐Ada) is the traditional polymer block. The average diameter of supramolecular micelles is ≈100 nm. Supramolecular micelles are able to control the release of the drugs in the cancer cells due to pH and redox microenvironments.