Temperature‐Sensitive (BA)(AC) 2 Miktoarm Star Diblock Copolymer Based on PMMA, PPEGMA, and PNIPAm

A well‐defined (BA)(AC) 2 miktoarm star diblock copolymer, (PPEGMA 32 ‐ b ‐PMMA 41 )‐ b ‐(PMMA 45 ‐ b ‐PNIPAm 19 ) 2 , is synthesized by the combination of ATRP and click reaction. The miktoarm star block copolymer and its precursors are characterized by means of NMR and SEC/MALLS measurements. The copolymer exhibits a low critical aggregation concentration in aqueous solution. Micelles that self‐assemble from the copolymer are prepared in aqueous solution below 15 °C by a sonication method. The micelles have a PMMA core and a PPEGMA/PNIPAm corona and exhibit temperature sensitivity. Using celecoxib as a guest molecule, it is found that the loading capacity of the star copolymer is 8.8 wt% and the celecoxib release from the loaded self‐assembly is temperature tunable.