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Temperature‐Sensitive (BA)(AC) 2 Miktoarm Star Diblock Copolymer Based on PMMA, PPEGMA, and PNIPAm
Author(s) -
Zhu Jie,
Liu Yuyang,
Xiao Liqun,
Zhou Ping
Publication year - 2016
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201500449
Subject(s) - copolymer , micelle , materials science , polymer chemistry , aqueous solution , star (game theory) , polymer , chemical engineering , chemistry , composite material , organic chemistry , engineering , mathematical analysis , mathematics
A well‐defined (BA)(AC) 2 miktoarm star diblock copolymer, (PPEGMA 32 ‐ b ‐PMMA 41 )‐ b ‐(PMMA 45 ‐ b ‐PNIPAm 19 ) 2 , is synthesized by the combination of ATRP and click reaction. The miktoarm star block copolymer and its precursors are characterized by means of NMR and SEC/MALLS measurements. The copolymer exhibits a low critical aggregation concentration in aqueous solution. Micelles that self‐assemble from the copolymer are prepared in aqueous solution below 15 °C by a sonication method. The micelles have a PMMA core and a PPEGMA/PNIPAm corona and exhibit temperature sensitivity. Using celecoxib as a guest molecule, it is found that the loading capacity of the star copolymer is 8.8 wt% and the celecoxib release from the loaded self‐assembly is temperature tunable.