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Multifunctional Amphiphilic Nanoparticles Featuring (Bio)Degradable Core and Dual‐Responsive Shell as Biomedical Platforms for Controlled Release
Author(s) -
Gromadzki Daniel,
Rychter Piotr,
Uchman Mariusz,
Momekova Denitsa,
Marcinkowski Andrzej,
Koseva Neli S.,
El Fray Miroslawa,
Marić Milan
Publication year - 2015
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201500235
Subject(s) - polyester , methacrylate , amphiphile , materials science , dynamic light scattering , nanoparticle , polymer chemistry , polymer , chemical engineering , drug delivery , copolymer , nanocarriers , nanotechnology , chemistry , composite material , engineering
Multifunctional polymeric platforms combining (bio)degradable and biocompatible, temperature and pH‐sensitive entities hold great promise as nanocarriers for targeted drug and gene delivery, and tissue engineering. In this work, preparation and characterization of surfactant‐free polyester nanoparticles (NPs) from biobased polyesters poly(butylene sebacate) (PBSE) and poly(butylene sebacate‐ co ‐butylene dilinoleate)s (PBSE/PBDL) using nanoprecipitation is reported. This strategy leads to spherical nanosized particles with sizes narrowly distributed in a range of 30–200 nm which is appropriate for internalization by a variety of cells. The effect of molecular parameters and type of solvent used in the nanoprecipitation protocol on the size and shape of produced polyester nanocolloids and their in vitro degradation in PBS solution at 37 °C is elucidated by quasi‐elastic light scattering (QELS), atomic force microscopy (AFM), transmission electron microscopy (TEM), and size‐exclusion chromatography (SEC) techniques. A dense cationic brush layer (≈ 20 nm) of stimuli‐responsive and biocompatible poly(2‐dimethylaminoethyl methacrylate‐ co ‐acrylonitrile) is grafted on the surface of PBSE/PBDL NPs through “grafting onto” (arm first) coupling chemistry.