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A Redox‐Responsive Supramolecular Hydrogel for Controllable Dye Release
Author(s) -
Ji Wei,
Liu Guo Feng,
Xu Ming Xin,
Feng Chuan Liang
Publication year - 2015
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201500210
Subject(s) - fourier transform infrared spectroscopy , supramolecular chemistry , self healing hydrogels , redox , chemistry , nanomedicine , polymer chemistry , hydrogen bond , circular dichroism , combinatorial chemistry , materials science , nanotechnology , chemical engineering , organic chemistry , molecule , nanoparticle , crystallography , engineering
A novel and simple strategy for preparing a redox‐responsive supramolecular hydrogel coassembled from phenylalanine derivative gelator and 4,4′‐dipyridine disulfide is reported in this study. The driving force for the coassembly process is intermolecular hydrogen bonds, as confirmed by various characterization methods, such as 1 H NMR, Fourier transform infrared (FTIR) spectroscopy, and circular dichroism spectroscopy. The disulfide‐containing nanofibrous hydrogel is able to control over the release of encapsulated dyes in response to the reductive condition mimicking the intracellular environment like tumor tissues and should be a promising system for controllable drug release in the fields of nanomedicine and cancer therapy.