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Salting‐Out Waterborne Catiomeric Polyurethanes for Drugs Encapsulation and Delivery
Author(s) -
Fernándezd'Arlas Borja,
Eceiza Arantxa
Publication year - 2015
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201500202
Subject(s) - micelle , polyurethane , kinetics , salting out , copolymer , chemical engineering , template , drug delivery , polymer chemistry , materials science , dynamic light scattering , chemistry , nanotechnology , polymer , organic chemistry , nanoparticle , aqueous solution , physics , quantum mechanics , engineering
Novel polyurethane (PU) catiomers with high urethane density are explored as templates for self‐assembling into drug‐carrying nanomicelles via a salting‐out method. The micelles sizes, the salting‐out efficiency, and drug encapsulation efficiency have been analyzed by dynamic light scattering and UV–vis. The ratio catiomeric/hydrophobic in the PU blocks structure influences the micelle hydrodynamic diameters varying from ≈50 to 200 nm. The encapsulating efficiencies of different model drugs (MDs) have been analyzed. The influence of MD nature and PU catiomeric/hydrophobic blocks ratio on MD release kinetics has been evaluated, showing how PU, MD nature, and the pH influence on the MD release patterns. These results pave the way to the design of tuned copolymers for controlled release kinetics of specific drugs.